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1

Unique Features in the Structure of the Complex between HIV-1 Reverse Transcriptase and the bis(Heteroaryl)Piperazine (BHAP) U-90152 Explain Resistance Mutations for this Nonnucleoside Inhibitor

Robert M. Esnouf, Jingshan Ren, Andrew L. Hopkins, Carl K. Ross, E. Yvonne Jones, David K. Stammers and David I. Stuart

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.66 MB

english, 1997

2

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

Achari, Aniruddha, Somers, Donald 0., Champness, John N., Bryant, Patrick .K., Rosemond, Jane, Stammers, David K.

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 1.15 MB

1997

3

Acute Effect of High-Intensity Interval Versus Moderate-Intensity Continuous Exercise on Blood Pressure and Arterial Compliance in Middle-Aged and Older Hypertensive Women With Increased Arterial Stiffness

Costa, Eduardo C., Kent, David E., Boreskie, Kevin F., Hay, Jacqueline L., Kehler, Dustin S., Edye-Mazowita, Alex, Nugent, Kristina, Papadopoulos, Josaphine, Stammers, Andrew N., Oldfield, Chris, Aror

Journal:

The Journal of Strength and Conditioning Research

Year:

2020

File:

PDF, 683 KB

2020

4

Contribution to the Development of Guidelines for Toll Plaza Design

McDonald Jr., David R., Stammer Jr., Robert E.

Journal:

Journal of Transportation Engineering

Year:

2001

Language:

english

File:

PDF, 70 KB

english, 2001

5

[IEEE 2015 IEEE Conference on Computational Intelligence and Games (CIG) - Tainan, Taiwan (2015.8.31-2015.9.2)] 2015 IEEE Conference on Computational Intelligence and Games (CIG) - Player-adaptive Spelunky level generation

Stammer, David, Mannheim, Hochschule, Gunther, Tobias, Preuss, Mike

Year:

2015

Language:

english

File:

PDF, 460 KB

english, 2015

6

Impact of preoperative physical activity and depressive symptoms on post-cardiac surgical outcomes

Kehler, D. Scott, Stammers, Andrew N., Horne, David, Hiebert, Brett, Kaoukis, George, Duhamel, Todd A., Arora, Rakesh C., Harnish, Chris

Journal:

Year:

2019

Language:

english

File:

PDF, 794 KB

english, 2019

7

The role of tests of frontal executive function in the detection of mild dementia

Joanna Nathan, David Wilkinson, Sue Stammers, J. Lorraine Low

Journal:

International Journal of Geriatric Psychiatry

Year:

2001

Language:

english

File:

PDF, 109 KB

english, 2001

8

ChemInform Abstract: HEPT: From an Investigation of Lithiation of Nucleosides Towards a Rational Design of Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1

Hiromichi Tanaka, Hiroyuki Hayakawa, Kazuhiro Haraguchi, Tadashi Miyasaka, Richard T. Walker, E. De Clercq, Masanori Baba, David K. Stammers, David I. Stuart

Journal:

Year:

2000

File:

PDF, 27 KB

2000

9

The dynamic instability of microtubules is not modulated by α-tubulin tyrosinylation

Haitham Idriss, David K. Stammers, Carl K. Ross, Roy G. Burns

Journal:

Year:

1991

Language:

english

File:

PDF, 729 KB

english, 1991

10

Prophylactic therapy with lithium in elderly patients with unipolar major depression

David Wilkinson, Clive Holmes, Janet Woolford, Susan Stammers, Janine North

Journal:

International Journal of Geriatric Psychiatry

Year:

2002

Language:

english

File:

PDF, 52 KB

english, 2002

11

Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim

Lee F Kuyper, Janice M Garvey, David P Baccanari, John N Champness, David K Stammers, Christopher R Beddell

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 876 KB

english, 1996

12

Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains

Louise E Bird, Jingshan Ren, Joanne E Nettleship, Gert E Folkers, Raymond J Owens, David K Stammers

Journal:

BMC Structural Biology

Year:

2010

Language:

english

File:

PDF, 3.80 MB

english, 2010

13

Crystal structure of nitrogen regulatory protein IIANtrfromNeisseria meningitidis

Jingshan Ren, Sarah Sainsbury, Nick S Berrow, David Alderton, Joanne E Nettleship, David K Stammers, Nigel J Saunders, Raymond J Owens

Journal:

BMC Structural Biology

Year:

2005

Language:

english

File:

PDF, 1.53 MB

english, 2005

14

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design

Kamel El Omari, Nicola Solaroli, Anna Karlsson, Jan Balzarini, David K Stammers

Journal:

BMC Structural Biology

Year:

2006

Language:

english

File:

PDF, 1.49 MB

english, 2006

15

Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: An unusual Type II glyoxalase

Anna L. Stamp, Paul Owen, Kamel El Omari, Charles E. Nichols, Michael Lockyer, Heather K. Lamb, Ian G. Charles, Alastair R. Hawkins, David K. Stammers

Journal:

Protein Science

Year:

2010

Language:

english

File:

PDF, 592 KB

english, 2010

16

Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases

Charlie E. Nichols, Heather K. Lamb, Mike Lockyer, Ian G. Charles, Susan Pyne, Alastair R. Hawkins, David K. Stammers

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 3.34 MB

english, 2007

17

Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351

Anna L. Stamp, Paul Owen, Kamel El Omari, Michael Lockyer, Heather K. Lamb, Ian G. Charles, Alastair R. Hawkins, David K. Stammers

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2011

Language:

english

File:

PDF, 378 KB

english, 2011

18

Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138

Jingshan Ren, Charles E. Nichols, Anna Stamp, Phillip P. Chamberlain, Robert Ferris, Kurt L. Weaver, Steven A. Short, David K. Stammers

Journal:

Year:

2006

Language:

english

File:

PDF, 947 KB

english, 2006

19

Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities

Xiaoqiu Wu, Stefan Knapp, Anna Stamp, David K. Stammers, Hans Jörnvall, Stephen L. Dellaporta, Udo Oppermann

Journal:

Year:

2007

Language:

english

File:

PDF, 766 KB

english, 2007

20

Electron density map of apoferritin at 2.8-Å resolution

BANYARD, STEPHEN H., STAMMERS, DAVID K., HARRISON, PAULINE M.

Journal:

Year:

1978

File:

PDF, 729 KB

1978

21

Structure of pyruvate kinase and similarities with other enzymes: possible implications for protein taxonomy and evolution

Levine, Michael, Muirhead, Hilary, Stammers, David K., Stuart, David I.

Journal:

Year:

1978

File:

PDF, 494 KB

1978

22

10.1038/5787

Larder, Brendan A., Stammers, David K.

Journal:

Natural Structural Biology

Year:

1999

Language:

english

File:

PDF, 377 KB

english, 1999

23

10.1038/72398

Harlos, Karl, Schofield, Christopher J., Zhang, Zhihong, Ren, Jingshan, Stammers, David K., Baldwin, Jack E.

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 641 KB

english, 2000

24

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

Esnouf, Robert, Ren, Jingshan, Ross, Carl, Jones, Yvonne, Stammers, David, Stuart, David

Journal:

Natural Structural Biology

Year:

1995

File:

PDF, 1008 KB

1995

25

Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding

Masayo Kotaka, Balvinder Dhaliwal, Jingshan Ren, Charles E. Nichols, Richard Angell, Michael Lockyer, Alastair R. Hawkins, David K. Stammers

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 678 KB

english, 2006

26

Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium

Heather K. Lamb, Paul Thompson, Catherine Elliott, Ian G. Charles, Jamie Richards, Michael Lockyer, Nicholas Watkins, Charles Nichols, David K. Stammers, Clive R. Bagshaw, Alan Cooper, Alastair R. Haw

Journal:

Protein Science

Year:

2007

Language:

english

File:

PDF, 455 KB

english, 2007

27

Structural Basis for the Resilience of Efavirenz (DMP-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase

Jingshan Ren, John Milton, Kurt L. Weaver, Steven A. Short, David I. Stuart, David K. Stammers

Journal:

Year:

2000

Language:

english

File:

PDF, 421 KB

english, 2000

28

The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design

Jingshan Ren, Robert Esnouf, Andrew Hopkins, Carl Ross, Yvonne Jones, David Stammers, David Stuart

Journal:

Year:

1995

Language:

english

File:

PDF, 1.57 MB

english, 1995

29

Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus

Louise E Bird, Jingshan Ren, Jiancheng Zhang, Neale Foxwell, Alastair R Hawkins, Ian G Charles, David K Stammers

Journal:

Year:

2002

Language:

english

File:

PDF, 807 KB

english, 2002

30

Formatin of heterodimers of human-immunodeficiency-virus-type-1 reverse transcriptase by recombination of separately purified subunits

David K. STAMMERS, Carl K. ROSS, Haitham IDRISS, Denise M. LOWE

Journal:

Year:

1992

Language:

english

File:

PDF, 444 KB

english, 1992

31

Structure−Activity Relationship Studies of Novel Benzophenones Leading to the Discovery of a Potent, Next Generation HIV Nonnucleoside Reverse Transcriptase Inhibitor

Romines, Karen R., Freeman, George A., Schaller, Lee T., Cowan, Jill R., Gonzales, Steve S., Tidwell, Jeffrey H., Andrews, Clarence W., Stammers, David K., Hazen, Richard J., Ferris, Robert G.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 203 KB

english, 2006

32

Crystallographic Analysis of the Binding Modes of Thiazoloisoindolinone Non-Nucleoside Inhibitors to HIV-1 Reverse Transcriptase and Comparison with Modeling Studies

Ren, Jingshan, Esnouf, Robert M., Hopkins, Andrew L., Stuart, David I., Stammers, David K.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 169 KB

english, 1999

33

Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors

Hopkins, Andrew L., Ren, Jingshan, Esnouf, Robert M., Willcox, Benjamin E., Jones, E. Yvonne, Ross, Carl, Miyasaka, Tadashi, Walker, Richard T., Tanaka, Hiromichi, Stammers, David K.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 427 KB

english, 1996

34

Crystal Structures of HIV-1 Reverse Transcriptase in Complex with Carboxanilide Derivatives†,‡

Ren, Jingshan, Esnouf, Robert M., Hopkins, Andrew L., Warren, Jonathan, Balzarini, Jan, Stuart, David I., Stammers, David K.

Journal:

Year:

1998

Language:

english

File:

PDF, 287 KB

english, 1998

35

Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases†

Ren, Jingshan, Nichols, Charles E., Chamberlain, Philip P., Weaver, Kurt L., Short, Steven A., Chan, Joseph H., Kleim, Jörg-Peter, Stammers, David K.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 997 KB

english, 2007

36

Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 1.

Hopkins, Andrew L., Ren, Jingshan, Milton, John, Hazen, Richard J., Chan, Joseph H., Stuart, David I., Stammers, David K.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 790 KB

english, 2004

37

Reduction in potency and reversal of left-shifting activity of BW12C with the major and minor components of chicken hemoglobin

Raymond Wootton, David K. Stammers, Ralph D. White

Journal:

Year:

1986

Language:

english

File:

PDF, 470 KB

english, 1986

38

Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase

Balvinder Dhaliwal, Charles E. Nichols, Jingshan Ren, Michael Lockyer, Ian Charles, Alastair R. Hawkins, David K. Stammers

Journal:

Year:

2004

Language:

english

File:

PDF, 284 KB

english, 2004

39

Structural Analysis of the Recognition of the Negative Regulator NmrA and DNA by the Zinc Finger from the GATA-Type Transcription Factor AreA

Masayo Kotaka, Christopher Johnson, Heather K. Lamb, Alastair R. Hawkins, Jingshan Ren, David K. Stammers

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.37 MB

english, 2008

40

HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms of drug resistance

Jingshan Ren, David K. Stammers

Journal:

Trends in Pharmacological Sciences

Year:

2005

Language:

english

File:

PDF, 245 KB

english, 2005

41

Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase

Jingshan Ren, David K. Stammers

Journal:

Year:

2008

Language:

english

File:

PDF, 2.83 MB

english, 2008

42

2.0 Å X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue

David K Stammers, Aniruddha Achari, Donald O’N Somers, Patrick K Bryant, Jane Rosemond, David L Scott, John N Champness

Journal:

Year:

1999

Language:

english

File:

PDF, 352 KB

english, 1999

43

Cloning, expression, purification, and crystallisation of HIV-2 reverse transcriptase

Louise E Bird, Philip P Chamberlain, Guillaume B.E Stewart-Jones, Jingshan Ren, David I Stuart, David K Stammers

Journal:

Protein Expression and Purification

Year:

2003

Language:

english

File:

PDF, 222 KB

english, 2003

44

Editorial

David Royston, Alfred H. Stammers

Journal:

Journal of Cardiothoracic and Vascular Anesthesia

Year:

1997

Language:

english

File:

PDF, 80 KB

english, 1997

45

Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy

Muhammed Z. Cader, Jingshan Ren, Paul A. James, Louise E. Bird, Kevin Talbot, David K. Stammers

Journal:

Year:

2007

Language:

english

File:

PDF, 1.70 MB

english, 2007

46

Evolution of a novel 5-amino-acid insertion in the β3–β4 loop of HIV-1 reverse transcriptase

Marleen C.D.G. Huigen, Loek de Graaf, Dirk Eggink, Rob Schuurman, Viktor Müller, Anna Stamp, David K. Stammers, Charles A.B. Boucher, Monique Nijhuis

Journal:

Year:

2007

Language:

english

File:

PDF, 894 KB

english, 2007

47

High resolution structures of HIV-1 RT from four RT–inhibitor complexes

Ren, Jingshan, Esnouf, Robert, Garman, Elspeth, Somers, Donald, Ross, Carl, Kirby, Ian, Keeling, James, Darby, Graham, Jones, Yvonne, Stuart, David, Stammers, David

Journal:

Natural Structural Biology

Year:

1995

File:

PDF, 1.53 MB

1995

48

Three-dimensional structure of cat muscle pyruvate kinase at 6 Å resolution

David K. Stammers, Hilary Muirhead

Journal:

Journal of Molecular Biology

Year:

1975

Language:

english

File:

PDF, 6.55 MB

english, 1975

49

Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å

David I. Stuart, Michael Levine, Hilary Muirhead, David K. Stammers

Journal:

Journal of Molecular Biology

Year:

1979

Language:

english

File:

PDF, 10.77 MB

english, 1979

50

Three-dimensional structure of cat muscle pyruvate kinase at 3·1 Å resolution

David K. Stammers, Hilary Muirhead

Journal:

Journal of Molecular Biology

Year:

1977

Language:

english

File:

PDF, 593 KB

english, 1977